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class="breadcrumb-content-inner"> <div class="gva-breadcrumb-content"> <div id="block-gavias-financial-breadcrumbs" class="text-dark block gva-block-breadcrumb hidden-xs block-system block-system-breadcrumb-block no-title"> <div class="container"> <div class="breadcrumb-content-main"> <h2 class="page-title hide">Team </h2> <div class="hidden-breadcrumb-links"> <div class="content block-content"> <div class="breadcrumb-links"> <div class="content-inner"> <nav class="breadcrumb " role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> <span class=""> / </span> </li> <li> </li> <li> Rullo </li> <li></li> </ol> </nav> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div role="main" class="main main-page"> <div class="clearfix"></div> <div class="clearfix"></div> <div class="clearfix"></div> <div id="content" class="content content-full"> <div class="container"> <div class="content-main-inner"> <div class="row"> <div id="page-main-content" class="main-content col-xs-12 col-md-8 sb-r "> <div class="main-content-inner"> <div class="content-main"> <div class="region region-content"> <div id="block-gavias-financial-content" class="block block-system block-system-main-block no-title"> <div class="content block-content"> <!-- Start Display article for teaser page --> <!-- Start Display article for detail page --> <article data-history-node-id="558" about="/faculty-staff/jacob-rullo" class="node node-detail node--type-team node--promoted node--view-mode-full clearfix"> <div class="team-single-page"> <div class="team-name clearfix"> <div class="name"> Dr. Jacob Rullo <span class="heading"> MD, PhD, FRCSC</span> </div> <!--<div class="line"><span class="one"></span><span class="second"></span><span class="three"></span></div>--> </div> <div class="team-description"></div> <div class="team-info"> <div class="row"> <div class="col-lg-4 col-sm-12 col-xs-12"> <div class="team-image"> <img src="/sites/ophthalmology/files/team/Jacob%20Rullo%20update_0.jpg" alt="Dr. Jacob Rullo"> </div> </div> <div class="col-lg-8 col-sm-12 col-xs-12"> <div class="team-contact"> <div class="heading">Position(s)</div> <div class="job"> <div class="field field--name-field-team-position field--type-string field--label-hidden field__items"> <div class="field__item">Research Director</div> <div class="field__item">Assistant Professor</div> <div class="field__item">Research Clinician</div> </div> </div> <div class="heading">Contact Info</div> <div class="content-inner"></div> <div class="content-inner"> <div class="field field--name-field-team-contact field--type-string field--label-hidden field__items"> <div class="field__item">Neuro — Tel: 613-544-3400 x 3390 (Kim Normand)</div> <div class="field__item">Neuro — Fax: 613-544-3041</div> <div class="field__item">Oculoplastics — Tel: (613) 544-3400 x 2169 (Sue Martin)</div> <div class="field__item">Oculoplastics — Fax: (613) 544-5721</div> </div> </div> <div> <div class="content-inner"></div> <div class="content-inner"> <div class="field field--name-field-affiliation-link field--type-link field--label-above"> <div class="field__label">Affiliation link</div> <div class="field__item"><a href="https://www.researchgate.net/scientific-contributions/2160028121_Jacob_Rullo">https://www.researchgate.net/scientific-contributions/2160028121_Jacob_Rullo</a></div> </div> </div> <div class="content-inner"></div> </div> </div> </div> </div> </div> <hr> <div class="node__content clearfix"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><h4>Education</h4> <ul> <li>Ophthalmology Residency: Queen's University (2020)</li> <li>Medical School: University of Toronto (2015)</li> <li>PhD, Laboratory Medicine and Pathobiology, University of Toronto (2015)</li> </ul> <h4>Research Profile</h4> <p>My research focus is in characterizing differences in the ocular microenvironment with respect to the discovery of novel biomolecules/biomarkers, understanding intraocular immune mechanisms, and the immune biology of the external ocular surface.</p> <h4>Publications</h4> <ol> <li> <p>Wang Y, Wei Sim F, Patrick Wang MA, Oh RY, Ratzlaff T, <strong>Rullo J</strong>, Sharma S. Changes in Scleral Thickness Following Repeated Anti-vascular Endothelial Growth Factor Injections. <em>J Ophthalmic Vis Res</em>. 2022;17(2):196-201. doi:<a href="https://doi.org/10.18502/jovr.v17i2.10790">10.18502/jovr.v17i2.10790</a></p> </li> <li> <p>Lampen SIR, Quinn MP, Pike D, <strong>Rullo J</strong>, ten Hove MW. Thrombophlebitis-Mediated Polycranial Neuropathy Secondary to Herpes Zoster Ophthalmicus. <em>Journal of Neuro-Ophthalmology</em>. Published online January 10, 2022. doi:<a href="https://doi.org/10.1097/WNO.0000000000001435">10.1097/WNO.0000000000001435</a></p> </li> <li> <p>Wang P, Farmer JP, <strong>Rullo J</strong>. Minocycline-Induced Hyperpigmentation. <em>JAMA Dermatol</em>. 2021;157(8):992. doi:<a href="https://doi.org/10.1001/jamadermatol.2021.2211">10.1001/jamadermatol.2021.2211</a></p> </li> <li> <p>Curtis R, <strong>Rullo J</strong>. Severe Bilateral Conjunctivitis With Corneal Limbal Infiltrates Associated With Dupilumab Treatment. <em>JAMA Ophthalmol</em>. 2021;139(8):e212012. doi:<a href="https://doi.org/10.1001/jamaophthalmol.2021.2012">10.1001/jamaophthalmol.2021.2012</a></p> </li> <li> <p>Mehraban Far P, <strong>Rullo J</strong>, Farmer J, Urton T. Recurrent Uveitis Related to Ibrutinib for Treatment of Chronic Lymphocytic Leukemia. <em>Ocul Immunol Inflamm</em>. Published online February 4, 2021:1-4. doi:<a href="https://doi.org/10.1080/09273948.2020.1841802">10.1080/09273948.2020.1841802</a></p> </li> <li> <p><strong>Rullo J</strong>, Bae S, Far PM, et al. Measuring intraocular antibodies in eyes treated with anti-vascular endothelial growth factor. <em>Can J Ophthalmol</em>. 2020;55(3):263-271. doi:<a href="https://doi.org/10.1016/j.jcjo.2019.11.010">10.1016/j.jcjo.2019.11.010</a></p> </li> <li> <p><strong>Rullo J</strong>, Far PM, Quinn M, et al. Local oral and nasal microbiome diversity in age-related macular degeneration. <em>Sci Rep</em>. 2020;10(1):3862. doi:<a href="https://doi.org/10.1038/s41598-020-60674-3">10.1038/s41598-020-60674-3</a></p> </li> <li> <p><strong>Rullo J</strong>, Pennimpede T, Mehraban Far P, et al. Intraocular calcidiol: Uncovering a role for vitamin D in the eye. <em>J Steroid Biochem Mol Biol</em>. 2020;197:105536. doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.105536">10.1016/j.jsbmb.2019.105536</a></p> </li> <li> <p>Mehraban Far P, <strong>Rullo J</strong>, Kratky V. Use of telemedicine in the management of life-threatening periorbital necrotizing fasciitis in a remote community. <em>CJEM</em>. 2020;22(1):118-120. doi:<a href="https://doi.org/10.1017/cem.2019.422">10.1017/cem.2019.422</a></p> </li> <li> <p><strong>Rullo J</strong>, Mehraban Far P, Farmer JF, Clements-Baker M, Ten Hove M. A curious case of arteritis: infectious, inflammatory, or both. <em>Can J Ophthalmol</em>. 2019;54(6):e288-e292. doi:<a href="https://doi.org/10.1016/j.jcjo.2019.02.011">10.1016/j.jcjo.2019.02.011</a></p> </li> <li> <p>Liu DJ, <strong>Rullo J</strong>, Kratky V, Farmer J. Histiocytic sarcoma of the eyelid. <em>Saudi J Ophthalmol</em>. 2019;33(3):300-303. doi:<a href="https://doi.org/10.1016/j.sjopt.2019.07.001">10.1016/j.sjopt.2019.07.001</a></p> </li> <li> <p>Fine N, Dimitriou ID, <strong>Rullo J</strong>, et al. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation. <em>J Cell Biol</em>. 2016;215(1):107-119. doi:<a href="https://doi.org/10.1083/jcb.201603109">10.1083/jcb.201603109</a></p> </li> <li> <p>Sharma S, <strong>Rullo J</strong>, Sharma NA. The future of medical education in ophthalmology. <em>Can J Ophthalmol</em>. 2016;51(3):128-129. doi:<a href="https://doi.org/10.1016/j.jcjo.2016.03.003">10.1016/j.jcjo.2016.03.003</a></p> </li> <li> <p><strong>Rullo J</strong>, C Lloyd J. Clinically significant deterioration in the quality of vision as a result of subsurface nanoglistenings in a hydrophobic acrylic intraocular lens. <em>J Cataract Refract Surg</em>. 2014;40(2):336-337. doi:<a href="https://doi.org/10.1016/j.jcrs.2013.12.010">10.1016/j.jcrs.2013.12.010</a></p> </li> <li> <p>Becker HM, <strong>Rullo J</strong>, Chen M, et al. α1β1 integrin-mediated adhesion inhibits macrophage exit from a peripheral inflammatory lesion. <em>J Immunol</em>. 2013;190(8):4305-4314. doi:<a href="https://doi.org/10.4049/jimmunol.1202097">10.4049/jimmunol.1202097</a></p> </li> <li> <p><strong>Rullo J</strong>, Becker H, Hyduk SJ, et al. Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion. <em>J Cell Biol</em>. 2012;197(1):115-129. doi:<a href="https://doi.org/10.1083/jcb.201107140">10.1083/jcb.201107140</a></p> </li> <li> <p>Hyduk SJ, <strong>Rullo J</strong>, Cano AP, et al. Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation. <em>J Immunol</em>. 2011;187(8):4360-4368. doi:<a href="https://doi.org/10.4049/jimmunol.1003725">10.4049/jimmunol.1003725</a></p> </li> <li> <p>Patrick AL, <strong>Rullo J</strong>, Beaudin S, Liaw P, Fox-Robichaud AE. Hepatic leukocyte recruitment in response to time-limited expression of TNF-alpha and IL-1beta. <em>Am J Physiol Gastrointest Liver Physiol</em>. 2007;293(4):G663-672. doi:<a href="https://doi.org/10.1152/ajpgi.00070.2007">10.1152/ajpgi.00070.2007</a></p> </li> </ol> </div> <div class="field field--name-field-affiliation-link field--type-link field--label-above"> <div class="field__label">Affiliation link</div> <div class="field__item"><a href="https://www.researchgate.net/scientific-contributions/2160028121_Jacob_Rullo">https://www.researchgate.net/scientific-contributions/2160028121_Jacob_Rullo</a></div> </div> </div> </div> </article> <!-- End Display article for detail page --> </div> </div> </div> </div> </div> </div> <!-- Sidebar Left --> <!-- End Sidebar Left --> <!-- Sidebar Right --> <div class="col-lg-4 col-md-4 col-sm-12 col-xs-12 sidebar sidebar-right theiaStickySidebar"> <div class="sidebar-inner"> <div class="region region-sidebar-right"> <div id="block-donatebutton" class="block block-block-content block-block-contentb0c99a8d-e61b-4b4d-84aa-be87988688b1 no-title"> <div class="content block-content"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div><a class="btn-theme btn btn-sm" href="http://www.givetoqueens.ca/ophthalmology" style="float:right; 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