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Dr. Jacob Rullo MD, PhD, FRCSC
Dr. Jacob Rullo
Research Director
Assistant Professor
Research Clinician
Contact Info
Tel: 613-544-3400 x 3390 (Sue Martin)
Fax: 613-544-3041


  • Ophthalmology Residency: Queen's University (2020)
  • Medical School: University of Toronto (2015)
  • PhD, Laboratory Medicine and Pathobiology, University of Toronto (2015)

Research Profile

My research focus is in characterizing differences in the ocular microenvironment with respect to the discovery of novel biomolecules/biomarkers, understanding intraocular immune mechanisms, and the immune biology of the external ocular surface.


  1. Wang Y, Wei Sim F, Patrick Wang MA, Oh RY, Ratzlaff T, Rullo J, Sharma S. Changes in Scleral Thickness Following Repeated Anti-vascular Endothelial Growth Factor Injections. J Ophthalmic Vis Res. 2022;17(2):196-201. doi:10.18502/jovr.v17i2.10790

  2. Lampen SIR, Quinn MP, Pike D, Rullo J, ten Hove MW. Thrombophlebitis-Mediated Polycranial Neuropathy Secondary to Herpes Zoster Ophthalmicus. Journal of Neuro-Ophthalmology. Published online January 10, 2022. doi:10.1097/WNO.0000000000001435

  3. Wang P, Farmer JP, Rullo J. Minocycline-Induced Hyperpigmentation. JAMA Dermatol. 2021;157(8):992. doi:10.1001/jamadermatol.2021.2211

  4. Curtis R, Rullo J. Severe Bilateral Conjunctivitis With Corneal Limbal Infiltrates Associated With Dupilumab Treatment. JAMA Ophthalmol. 2021;139(8):e212012. doi:10.1001/jamaophthalmol.2021.2012

  5. Mehraban Far P, Rullo J, Farmer J, Urton T. Recurrent Uveitis Related to Ibrutinib for Treatment of Chronic Lymphocytic Leukemia. Ocul Immunol Inflamm. Published online February 4, 2021:1-4. doi:10.1080/09273948.2020.1841802

  6. Rullo J, Bae S, Far PM, et al. Measuring intraocular antibodies in eyes treated with anti-vascular endothelial growth factor. Can J Ophthalmol. 2020;55(3):263-271. doi:10.1016/j.jcjo.2019.11.010

  7. Rullo J, Far PM, Quinn M, et al. Local oral and nasal microbiome diversity in age-related macular degeneration. Sci Rep. 2020;10(1):3862. doi:10.1038/s41598-020-60674-3

  8. Rullo J, Pennimpede T, Mehraban Far P, et al. Intraocular calcidiol: Uncovering a role for vitamin D in the eye. J Steroid Biochem Mol Biol. 2020;197:105536. doi:10.1016/j.jsbmb.2019.105536

  9. Mehraban Far P, Rullo J, Kratky V. Use of telemedicine in the management of life-threatening periorbital necrotizing fasciitis in a remote community. CJEM. 2020;22(1):118-120. doi:10.1017/cem.2019.422

  10. Rullo J, Mehraban Far P, Farmer JF, Clements-Baker M, Ten Hove M. A curious case of arteritis: infectious, inflammatory, or both. Can J Ophthalmol. 2019;54(6):e288-e292. doi:10.1016/j.jcjo.2019.02.011

  11. Liu DJ, Rullo J, Kratky V, Farmer J. Histiocytic sarcoma of the eyelid. Saudi J Ophthalmol. 2019;33(3):300-303. doi:10.1016/j.sjopt.2019.07.001

  12. Fine N, Dimitriou ID, Rullo J, et al. GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation. J Cell Biol. 2016;215(1):107-119. doi:10.1083/jcb.201603109

  13. Sharma S, Rullo J, Sharma NA. The future of medical education in ophthalmology. Can J Ophthalmol. 2016;51(3):128-129. doi:10.1016/j.jcjo.2016.03.003

  14. Rullo J, C Lloyd J. Clinically significant deterioration in the quality of vision as a result of subsurface nanoglistenings in a hydrophobic acrylic intraocular lens. J Cataract Refract Surg. 2014;40(2):336-337. doi:10.1016/j.jcrs.2013.12.010

  15. Becker HM, Rullo J, Chen M, et al. α1β1 integrin-mediated adhesion inhibits macrophage exit from a peripheral inflammatory lesion. J Immunol. 2013;190(8):4305-4314. doi:10.4049/jimmunol.1202097

  16. Rullo J, Becker H, Hyduk SJ, et al. Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012;197(1):115-129. doi:10.1083/jcb.201107140

  17. Hyduk SJ, Rullo J, Cano AP, et al. Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation. J Immunol. 2011;187(8):4360-4368. doi:10.4049/jimmunol.1003725

  18. Patrick AL, Rullo J, Beaudin S, Liaw P, Fox-Robichaud AE. Hepatic leukocyte recruitment in response to time-limited expression of TNF-alpha and IL-1beta. Am J Physiol Gastrointest Liver Physiol. 2007;293(4):G663-672. doi:10.1152/ajpgi.00070.2007