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Dr. Isabella Irrcher
Dr. Isabella Irrcher
Position(s)
Research Coordinator
Assistant Professor
Contact Info
Tel: (613) 544-3400, ext. 2361
Fax: (613) 533-6667

Education:

Postdoctoral Fellowship: Ottawa Hospital Research Institute, Department of Neuroscience, University of Ottawa (2007-2010) Mentor: Dr. David S. Park
PhD: Faculty of Pure and Applied Science, Biology, York University (2007)
Msc: Faculty of Pure and Applied Science, Kinesiology and Health Science, York University (2001)
Undergraduate: Faculty of Pure and Applied Science, Kinesiology and Health Science, York University (1999)

Research Interests

Mitochondrial dysfunction in age-related eye disease

 

Selected Publications:

Jahani-Asl A, Huang E, Irrcher I, Rashidian J, Ishihara N, Lagace DC, Slack RS, Park DS. CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death. Hum Mol Genet. 2015 Aug 15;24(16):4573-83.

ten Hove MW, Friedman DI, Patel AD, Irrcher I, Wall M, McDermott MP; NORDIC Idiopathic Intracranial Hypertension Study Group. Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial.J Neuroophthalmol. 2016 Mar;36(1):13-9.

Jinapriya D, D'Souza M, Hollands H, El-Defrawy SR, Irrcher I, Smallman D, Farmer JP, Cheung J, Urton T, Day A, Sun X, Campbell RJ. Anti-inflammatory Therapy after Selective Laser Trabeculoplasty: A Randomized, Double-Masked, Placebo-Controlled Clinical Trial. Ophthalmology. 2014 Dec;121(12):2356-61.

Parsanejad M, Bourquard N, Qu D, Zhang Y, Huang E, Rousseaux MW, Aleyasin H, Irrcher I, Callaghan S, Vaillant DC, Kim RH, Slack RS, Mak TW, Reddy ST, Figeys D, Park DS. DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. PLoS One. 2014 Sep 11;9(9):e106601.

Parsanejad M, Zhang Y, Qu D, Irrcher I, Rousseaux MW, Aleyasin H, Kamkar F, Callaghan S, Slack RS, Mak TW, Lee S, Figeys D, Park DS. Regulation of the VHL/HIF-1 pathway by DJ-1. J Neurosci.  2014 Jun 4;34(23):8043-50.

Zhang Y, Uguccioni G, Ljubicic V, Irrcher I, Iqbal S, Singh K, Ding S, Hood DA. Multiple signaling pathways regulate contractile activity-mediated PGC-1α gene expression and activity in skeletal muscle cells. Physiol Rep. 2014 May 19;2(5).

Kis M, Saunders FW, Kis M Sr, Irrcher I, Tator CH, Bishop PJ, ten Hove MW. A method of evaluating helmet rotational acceleration protection using the Kingston Impact Simulator (KIS Unit). Clin J Sport Med.2013 Nov;23(6):470-7.

Jinapriya D, Almeida DRP, Johnson D, Irrcher I, El-Defrawy SR. Anaesthetic plus dilating gel improves pupil dilation for cataract surgery. Can J Ophthalmol 2012 Apr; 47(2): 145-9.

Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 2011 May;18(5):769-82.

Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet. 2010 Oct 1;19(19):3734-46.

Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3186-91.

Irrcher I, Park DS. Parkinson's disease: to live or die by autophagy. Sci Signal. 2009 Apr 7;2(65):pe21.

Other Publications.